Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial

BACKGROUND: Potassium depletion by thiazide diuretics is associated with a rise in blood glucose. We assessed whether addition or substitution of a potassium-sparing diuretic, amiloride, to treatment with a thiazide can prevent glucose intolerance and improve blood pressure control. METHODS: We did...

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Detalhes bibliográficos
Publicado no:Lancet Diabetes Endocrinol
Main Authors: Brown, Morris J, Williams, Bryan, Morant, Steve V, Webb, David J, Caulfield, Mark J, Cruickshank, J Kennedy, Ford, Ian, McInnes, Gordon, Sever, Peter, Salsbury, Jackie, Mackenzie, Isla S, Padmanabhan, Sandosh, MacDonald, Thomas M
Formato: Artigo
Idioma:Inglês
Publicado em: The Lancet, Diabetes & Endocrinology 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728199/
https://ncbi.nlm.nih.gov/pubmed/26489809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2213-8587(15)00377-0
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