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Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

Crosstalk between cellular metabolism and the epigenome regulates epigenetic and metabolic homeostasis and normal cell behavior. Changes in cancer cell metabolism can directly impact epigenetic regulation and promote transformation. Here we analyzed the contribution of methionine and serine metaboli...

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Publicat a:Mol Cell
Autors principals: Maddocks, Oliver D.K., Labuschagne, Christiaan F., Adams, Peter D., Vousden, Karen H.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728077/
https://ncbi.nlm.nih.gov/pubmed/26774282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.014
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