Folate-Targeted pH-Responsive Calcium Zoledronate Nanoscale Metal-Organic Frameworks: Turning A Bone Antiresorptive Agent Into An Anticancer Therapeutics

Zoledronate (Zol) is a third-generation bisphosphonate that is widely used as an anti-resorptive agent for the treatment of cancer bone metastasis. While there is preclinical data indicating that bisphosphonates such as Zol have direct cytotoxic effects on cancer cells, such effect has not been firm...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Au, Kin Man, Satterlee, Andrew, Min, Yuanzeng, Tian, Xi, Kim, Young Seok, Caster, Joseph M., Zhang, Longzhen, Zhang, Tian, Huang, Leaf, Wang, Andrew Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728024/
https://ncbi.nlm.nih.gov/pubmed/26763733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.12.018
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