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Turning an antiviral into an anticancer drug: Nanoparticle delivery of acyclovir monophosphate
Anti-herpes simplex virus (HSV) drug acyclovir (ACV) is phosphorylated by the viral thymidine kinase (TK), but not the cellular TK. Phosphorylated ACV inhibits cellular DNA synthesis and kills the infected cells. We hypothesize that ACV monophosphate (ACVP), which is an activated metabolite of ACV,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742590/ https://ncbi.nlm.nih.gov/pubmed/23791977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.06.009 |
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