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Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice

GLO1 (Glyoxalase1) is a ubiquitous cellular enzyme that detoxifies methylglyoxal (MG), which is a byproduct of glycolysis. Previously, we showed that ubiquitous overexpression of Glo1 reduced concentrations of MG and increased anxiety-like behavior, whereas systemic injection of MG reduced anxiety-l...

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Vydáno v:Behav Brain Res
Hlavní autoři: McMurray, K. M. J., Du, X., Brownlee, M., Palmer, A. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728018/
https://ncbi.nlm.nih.gov/pubmed/26711908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2015.12.026
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