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Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats

Background. This study was to explore the pharmacokinetics of saxagliptin (Sax) in Goto–Kakizaki (GK) rats complicated with depression induced by chronic unpredicted mild stress (CUMS). The comorbidity of diabetic patients with depression is becoming more and more epidemic. Whether depression mental...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PeerJ
Hauptverfasser: Xia, Zhengchao, Wei, Hongyan, Duan, Jingjing, Zhou, Ting, Yang, Zhen, Xu, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: PeerJ Inc. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727972/
https://ncbi.nlm.nih.gov/pubmed/26819853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.1611
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