Selective proteolytic activity of the antitumor agent kedarcidin.

Kedarcidin is a potent antitumor antibiotic chromoprotein, composed of an enediyne-containing chromophore embedded in a highly acidic single chain polypeptide. The chromophore was shown to cleave duplex DNA site-specifically in a single-stranded manner. Herein, we report that in vitro, the kedarcidi...

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Detaylı Bibliyografya
Asıl Yazarlar: Zein, N, Casazza, A M, Doyle, T W, Leet, J E, Schroeder, D R, Solomon, W, Nadler, S G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1993
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC47277/
https://ncbi.nlm.nih.gov/pubmed/8367457
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