Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS.

We are investigating a strategy for somatic gene therapy to treat human immunodeficiency virus type 1 (HIV-1) infection by intracellular expression of an RNA decoy and a ribozyme. The RNA decoy, consisting of polymeric Tat activation response elements (TARs), is designed to compete for Tat binding i...

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Hauptverfasser: Lisziewicz, J, Sun, D, Smythe, J, Lusso, P, Lori, F, Louie, A, Markham, P, Rossi, J, Reitz, M, Gallo, R C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC47275/
https://ncbi.nlm.nih.gov/pubmed/8367455
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