Improving power and accuracy of genome-wide association studies via a multi-locus mixed linear model methodology

Genome-wide association studies (GWAS) have been widely used in genetic dissection of complex traits. However, common methods are all based on a fixed-SNP-effect mixed linear model (MLM) and single marker analysis, such as efficient mixed model analysis (EMMA). These methods require Bonferroni corre...

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Publicado no:Sci Rep
Main Authors: Wang, Shi-Bo, Feng, Jian-Ying, Ren, Wen-Long, Huang, Bo, Zhou, Ling, Wen, Yang-Jun, Zhang, Jin, Dunwell, Jim M., Xu, Shizhong, Zhang, Yuan-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726296/
https://ncbi.nlm.nih.gov/pubmed/26787347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19444
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