Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

The mortality and morbidity rates of pancreatic cancer are high because of its extremely invasive and metastatic nature. Its lack of symptoms, late diagnosis and chemo–resistance and the ineffective treatment modalities warrant the development of new chemo–therapeutic agents for pancreatic cancer. A...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Subramani, Ramadevi, Gonzalez, Elizabeth, Arumugam, Arunkumar, Nandy, Sushmita, Gonzalez, Viviana, Medel, Joshua, Camacho, Fernando, Ortega, Andrew, Bonkoungou, Sandrine, Narayan, Mahesh, Dwivedi, Alok kumar, Lakshmanaswamy, Rajkumar
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726267/
https://ncbi.nlm.nih.gov/pubmed/26804739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19819
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