SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination

Cranial neural crest cells (CNCCs) delaminate from embryonic neural folds and migrate to pharyngeal arches, which give rise to most mid-facial structures. CNCC dysfunction plays a prominent role in the etiology of orofacial clefts, a frequent birth malformation. Heterozygous mutations in SPECC1L hav...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Wilson, Nathan R., Olm-Shipman, Adam J., Acevedo, Diana S., Palaniyandi, Kanagaraj, Hall, Everett G., Kosa, Edina, Stumpff, Kelly M., Smith, Guerin J., Pitstick, Lenore, Liao, Eric C., Bjork, Bryan C., Czirok, Andras, Saadi, Irfan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726231/
https://ncbi.nlm.nih.gov/pubmed/26787558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17735
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