SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination

Cranial neural crest cells (CNCCs) delaminate from embryonic neural folds and migrate to pharyngeal arches, which give rise to most mid-facial structures. CNCC dysfunction plays a prominent role in the etiology of orofacial clefts, a frequent birth malformation. Heterozygous mutations in SPECC1L hav...

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發表在:Sci Rep
Main Authors: Wilson, Nathan R., Olm-Shipman, Adam J., Acevedo, Diana S., Palaniyandi, Kanagaraj, Hall, Everett G., Kosa, Edina, Stumpff, Kelly M., Smith, Guerin J., Pitstick, Lenore, Liao, Eric C., Bjork, Bryan C., Czirok, Andras, Saadi, Irfan
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726231/
https://ncbi.nlm.nih.gov/pubmed/26787558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17735
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