SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination

Cranial neural crest cells (CNCCs) delaminate from embryonic neural folds and migrate to pharyngeal arches, which give rise to most mid-facial structures. CNCC dysfunction plays a prominent role in the etiology of orofacial clefts, a frequent birth malformation. Heterozygous mutations in SPECC1L hav...

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Publicado no:Sci Rep
Main Authors: Wilson, Nathan R., Olm-Shipman, Adam J., Acevedo, Diana S., Palaniyandi, Kanagaraj, Hall, Everett G., Kosa, Edina, Stumpff, Kelly M., Smith, Guerin J., Pitstick, Lenore, Liao, Eric C., Bjork, Bryan C., Czirok, Andras, Saadi, Irfan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726231/
https://ncbi.nlm.nih.gov/pubmed/26787558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17735
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