Reduction of Oxidative Stress in Chronic Kidney Disease Does Not Increase Circulating α-Klotho Concentrations

The CKD-associated decline in soluble α-Klotho levels is considered detrimental. Some in vitro and in vivo animal studies have shown that anti-oxidant therapy can upregulate the expression of α-Klotho in the kidney. We examined the effect of anti-oxidant therapy on α-Klotho concentrations in a clini...

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Vydáno v:PLoS One
Hlavní autoři: Adema, Aaltje Y., van Ittersum, Frans J., Hoenderop, Joost G., de Borst, Martin H., Nanayakkara, Prabath W., Ter Wee, Piet M., Heijboer, Annemieke C., Vervloet, Marc G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725669/
https://ncbi.nlm.nih.gov/pubmed/26807718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144121
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