Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Since the linking of mutations in the Cu,Zn superoxide dismutase gene (sod1) to amyotrophic lateral sclerosis (ALS) in 1993, researchers have sought the connection between SOD1 and motor neuron death. Disease-linked mutations tend to destabilize the native dimeric structure of SOD1, and plaques cont...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Proctor, Elizabeth A., Fee, Lanette, Tao, Yazhong, Redler, Rachel L., Fay, James M., Zhang, Yuliang, Lv, Zhengjian, Mercer, Ian P., Deshmukh, Mohanish, Lyubchenko, Yuri L., Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725519/
https://ncbi.nlm.nih.gov/pubmed/26719414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516725113
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares