Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Since the linking of mutations in the Cu,Zn superoxide dismutase gene (sod1) to amyotrophic lateral sclerosis (ALS) in 1993, researchers have sought the connection between SOD1 and motor neuron death. Disease-linked mutations tend to destabilize the native dimeric structure of SOD1, and plaques cont...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Proctor, Elizabeth A., Fee, Lanette, Tao, Yazhong, Redler, Rachel L., Fay, James M., Zhang, Yuliang, Lv, Zhengjian, Mercer, Ian P., Deshmukh, Mohanish, Lyubchenko, Yuri L., Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725519/
https://ncbi.nlm.nih.gov/pubmed/26719414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516725113
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados