Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence

Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS), designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best characterized is ESX-1, which profoundly impacts host cell interactions. In contrast, the ESX-3 T7SS is implicated in metal homeostasis, bu...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Tufariello, JoAnn M., Chapman, Jessica R., Kerantzas, Christopher A., Wong, Ka-Wing, Vilchèze, Catherine, Jones, Christopher M., Cole, Laura E., Tinaztepe, Emir, Thompson, Victor, Fenyö, David, Niederweis, Michael, Ueberheide, Beatrix, Philips, Jennifer A., Jacobs, William R.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725510/
https://ncbi.nlm.nih.gov/pubmed/26729876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523321113
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