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Colon-specific drug delivery systems based on cyclodextrin prodrugs: In vivo evaluation of 5-aminosalicylic acid from its cyclodextrin conjugates

AIM: To investigate the release of cyclodextrin-5-aminosalicylic acid (CyD-5-ASA) in cecum and colon. METHODS: An anti-inflammatory drug 5-ASA was conjugated onto the hydroxyl groups of α-, β- and γ-cyclodextrins (CyDs) through an ester linkage, and the in vivo drug release behavior of these prodrug...

詳細記述

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書誌詳細
出版年:World J Gastroenterol
主要な著者: Zou, Mei-Juan, Cheng, Gang, Okamoto, Hirokazu, Hao, Xiu-Hua, An, Feng, Cui, Fu-De, Danjo, Kazumi
フォーマット: Artigo
言語:Inglês
出版事項: Baishideng Publishing Group Inc 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725178/
https://ncbi.nlm.nih.gov/pubmed/16437716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i47.7457
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