Colon-specific drug delivery systems based on cyclodextrin prodrugs: In vivo evaluation of 5-aminosalicylic acid from its cyclodextrin conjugates

AIM: To investigate the release of cyclodextrin-5-aminosalicylic acid (CyD-5-ASA) in cecum and colon. METHODS: An anti-inflammatory drug 5-ASA was conjugated onto the hydroxyl groups of α-, β- and γ-cyclodextrins (CyDs) through an ester linkage, and the in vivo drug release behavior of these prodrug...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Zou, Mei-Juan, Cheng, Gang, Okamoto, Hirokazu, Hao, Xiu-Hua, An, Feng, Cui, Fu-De, Danjo, Kazumi
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2005
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725178/
https://ncbi.nlm.nih.gov/pubmed/16437716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i47.7457
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