Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases

[Image: see text] Members of the same protease family show different substrate specificity, even if they share identical folds, depending on the physiological processes they are part of. Here, we investigate the key factors for subpocket and global specificity of factor Xa, elastase, and granzyme B...

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Publicat a:J Phys Chem B
Autors principals: Waldner, Birgit J., Fuchs, Julian E., Huber, Roland G., von Grafenstein, Susanne, Schauperl, Michael, Kramer, Christian, Liedl, Klaus R.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724848/
https://ncbi.nlm.nih.gov/pubmed/26709959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b10637
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