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Inhibition of phosphoinositide 3-kinase delta attenuates experimental autoimmune encephalomyelitis in mice

The phosphoinositide 3-kinase delta (PI3Kδ) has been implicated in multiple signaling pathways involved in autoimmune diseases. We here aimed to test the hypothesis that selective inhibition of PI3Kδ may promote anti-inflammatory effects by inhibiting Th1 and Th17 cells. We investigated the therapeu...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Clin Exp Med
Hauptverfasser: Shang, Shi-Qiang, Li, Jian, Li, Shu-Qing, Cao, Yu-Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723830/
https://ncbi.nlm.nih.gov/pubmed/26884985
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