A New Generation of FRET Sensors for Robust Measurement of Gα(i1), Gα(i2) and Gα(i3) Activation Kinetics in Single Cells

G-protein coupled receptors (GPCRs) can activate a heterotrimeric G-protein complex with subsecond kinetics. Genetically encoded biosensors based on Förster resonance energy transfer (FRET) are ideally suited for the study of such fast signaling events in single living cells. Here we report on the c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: van Unen, Jakobus, Stumpf, Anette D., Schmid, Benedikt, Reinhard, Nathalie R., Hordijk, Peter L., Hoffmann, Carsten, Gadella, Theodorus W. J., Goedhart, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723041/
https://ncbi.nlm.nih.gov/pubmed/26799488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146789
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