Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia

BACKGROUND: Chronic lymphocytic leukemia (CLL) primarily affects older persons who often have coexisting conditions in addition to disease-related immunosuppression and myelosuppression. We conducted an international, open-label, randomized phase 3 trial to compare two oral agents, ibrutinib and chl...

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Publicado en:N Engl J Med
Main Authors: Burger, Jan A., Tedeschi, Alessandra, Barr, Paul M., Robak, Tadeusz, Owen, Carolyn, Ghia, Paolo, Bairey, Osnat, Hillmen, Peter, Bartlett, Nancy L., Li, Jianyong, Simpson, David, Grosicki, Sebastian, Devereux, Stephen, McCarthy, Helen, Coutre, Steven, Quach, Hang, Gaidano, Gianluca, Maslyak, Zvenyslava, Stevens, Don A., Janssens, Ann, Offner, Fritz, Mayer, Jiří, O'Dwyer, Michael, Hellmann, Andrzej, Schuh, Anna, Siddiqi, Tanya, Polliack, Aaron, Tam, Constantine S., Suri, Deepali, Cheng, Mei, Clow, Fong, Styles, Lori, James, Danelle F., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722809/
https://ncbi.nlm.nih.gov/pubmed/26639149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1509388
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