Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia

BACKGROUND: Chronic lymphocytic leukemia (CLL) primarily affects older persons who often have coexisting conditions in addition to disease-related immunosuppression and myelosuppression. We conducted an international, open-label, randomized phase 3 trial to compare two oral agents, ibrutinib and chl...

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Detalhes bibliográficos
Publicado no:N Engl J Med
Main Authors: Burger, Jan A., Tedeschi, Alessandra, Barr, Paul M., Robak, Tadeusz, Owen, Carolyn, Ghia, Paolo, Bairey, Osnat, Hillmen, Peter, Bartlett, Nancy L., Li, Jianyong, Simpson, David, Grosicki, Sebastian, Devereux, Stephen, McCarthy, Helen, Coutre, Steven, Quach, Hang, Gaidano, Gianluca, Maslyak, Zvenyslava, Stevens, Don A., Janssens, Ann, Offner, Fritz, Mayer, Jiří, O'Dwyer, Michael, Hellmann, Andrzej, Schuh, Anna, Siddiqi, Tanya, Polliack, Aaron, Tam, Constantine S., Suri, Deepali, Cheng, Mei, Clow, Fong, Styles, Lori, James, Danelle F., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722809/
https://ncbi.nlm.nih.gov/pubmed/26639149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1509388
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