Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease

BACKGROUND: Parkinson disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy Bodies” within neurons. PD has both genetic and environmental risk factors, and while processes leading to aberrant protein aggr...

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Detalhes bibliográficos
Publicado no:BMC Med Genomics
Main Authors: Dumitriu, Alexandra, Golji, Javad, Labadorf, Adam T., Gao, Benbo, Beach, Thomas G., Myers, Richard H., Longo, Kenneth A., Latourelle, Jeanne C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722694/
https://ncbi.nlm.nih.gov/pubmed/26793951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-016-0164-y
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