The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane

Genome-wide association studies (GWAS) have identified the GAK/DGKQ/IDUA region on 4p16.3 among the top three risk loci for Parkinson’s disease (PD), but the specific gene and risk mechanism are unclear. Here, we report transcripts containing the 3’ clathrin-binding domain of GAK identified by RNA d...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nagle, Michael W., Latourelle, Jeanne C., Labadorf, Adam, Dumitriu, Alexandra, Hadzi, Tiffany C., Beach, Thomas G., Myers, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980018/
https://ncbi.nlm.nih.gov/pubmed/27508417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160925
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