Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease

Neuropeptide Y (NPY) is one of the most abundant protein transmitters in the central nervous system with roles in a variety of biological functions including: food intake, cardiovascular regulation, cognition, seizure activity, circadian rhythms, and neurogenesis. Reduced NPY and NPY receptor expres...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Spencer, Brian, Potkar, Rewati, Metcalf, Jeff, Thrin, Ivy, Adame, Anthony, Rockenstein, Edward, Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722467/
https://ncbi.nlm.nih.gov/pubmed/26620558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678185
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