Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor

Crystallographic evidence suggests that the pH-dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity at mildly acidic conditions. However, this view does not explain the div...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Walters, Benjamin T., Jensen, Pernille F., Larraillet, Vincent, Lin, Kevin, Patapoff, Thomas, Schlothauer, Tilman, Rand, Kasper D., Zhang, Jennifer
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722460/
https://ncbi.nlm.nih.gov/pubmed/26627822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691568
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