Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor

Crystallographic evidence suggests that the pH-dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity at mildly acidic conditions. However, this view does not explain the div...

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Publicado en:J Biol Chem
Autores principales: Walters, Benjamin T., Jensen, Pernille F., Larraillet, Vincent, Lin, Kevin, Patapoff, Thomas, Schlothauer, Tilman, Rand, Kasper D., Zhang, Jennifer
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722460/
https://ncbi.nlm.nih.gov/pubmed/26627822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691568
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