Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor

Crystallographic evidence suggests that the pH-dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity at mildly acidic conditions. However, this view does not explain the div...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Walters, Benjamin T., Jensen, Pernille F., Larraillet, Vincent, Lin, Kevin, Patapoff, Thomas, Schlothauer, Tilman, Rand, Kasper D., Zhang, Jennifer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722460/
https://ncbi.nlm.nih.gov/pubmed/26627822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691568
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