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Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity

Diverse lines of evidence suggest that amyloid-β (Aβ) peptides causally contribute to the pathogenesis of Alzheimer disease (AD), the most frequent neurodegenerative disorder. However, the mechanisms by which Aβ impairs neuronal functions remain to be fully elucidated. Previous studies showed that s...

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Vydáno v:J Biol Chem
Hlavní autoři: Miyamoto, Takashi, Kim, Daniel, Knox, Joseph A., Johnson, Erik, Mucke, Lennart
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722453/
https://ncbi.nlm.nih.gov/pubmed/26589795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666529
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