Genomic Instability in Mice Lacking Histone H2AX

Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is associated with the recruitment of repair factors to damaged DNA. To help clarify the physiological role of H2AX, we targeted H2A...

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Publicat a:Science
Autors principals: Celeste, Arkady, Petersen, Simone, Romanienko, Peter J., Fernandez-Capetillo, Oscar, Chen, Hua Tang, Sedelnikova, Olga A., Reina-San-Martin, Bernardo, Coppola, Vincenzo, Meffre, Eric, Difilippantonio, Michael J., Redon, Christophe, Pilch, Duane R., Olaru, Alexandru, Eckhaus, Michael, Camerini-Otero, R. Daniel, Tessarollo, Lino, Livak, Ferenc, Manova, Katia, Bonner, William M., Nussenzweig, Michel C., Nussenzweig, Andre
Format: Artigo
Idioma:Inglês
Publicat: 2002
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721576/
https://ncbi.nlm.nih.gov/pubmed/11934988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1069398
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