Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain

Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors. Of these, group III mGlu receptors (mGlu 4, 6, 7, 8) are among the least studied due to a lack of pharmacological tools. mGlu7 receptors, the most highly co...

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Detalhes bibliográficos
Publicado no:Neurobiol Stress
Main Authors: Moloney, Rachel D., Golubeva, Anna V., O'Connor, Richard M., Kalinichev, Mikhail, Dinan, Timothy G., Cryan, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721404/
https://ncbi.nlm.nih.gov/pubmed/26844237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynstr.2015.04.001
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