Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain

Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors. Of these, group III mGlu receptors (mGlu 4, 6, 7, 8) are among the least studied due to a lack of pharmacological tools. mGlu7 receptors, the most highly co...

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Publicat a:Neurobiol Stress
Autors principals: Moloney, Rachel D., Golubeva, Anna V., O'Connor, Richard M., Kalinichev, Mikhail, Dinan, Timothy G., Cryan, John F.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
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Original Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721404/
https://ncbi.nlm.nih.gov/pubmed/26844237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynstr.2015.04.001
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