Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model

The NaKCl cotransporter NKCC1 facilitates intraneuronal chloride accumulation in the developing brain. Bumetanide, a clinically available diuretic, inhibits this chloride transporter, and augments the antiepileptic effects of phenobarbital in neonatal rodents. In a neonatal cerebral hypoxia-ischemia...

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Bibliographic Details
Published in:Pediatr Res
Main Authors: Liu, YiQing, Shangguan, Yu, Barks, John D.E., Silverstein, Faye S.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721236/
https://ncbi.nlm.nih.gov/pubmed/22398701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2012.7
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