Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

Leber's hereditary optic neuropathy (LHON), the most frequent mitochondrial disease, is associated with mitochondrial DNA (mtDNA) point mutations affecting Complex I subunits, usually homoplasmic. This blinding disorder is characterized by incomplete penetrance, possibly related to several gene...

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Publicado en:Cell Death Dis
Autores principales: Giordano, L, Deceglie, S, d'Adamo, P, Valentino, M L, La Morgia, C, Fracasso, F, Roberti, M, Cappellari, M, Petrosillo, G, Ciaravolo, S, Parente, D, Giordano, C, Maresca, A, Iommarini, L, Del Dotto, V, Ghelli, A M, Salomao, S R, Berezovsky, A, Belfort, R, Sadun, A A, Carelli, V, Loguercio Polosa, P, Cantatore, P
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720897/
https://ncbi.nlm.nih.gov/pubmed/26673666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.364
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