Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

Leber's hereditary optic neuropathy (LHON), the most frequent mitochondrial disease, is associated with mitochondrial DNA (mtDNA) point mutations affecting Complex I subunits, usually homoplasmic. This blinding disorder is characterized by incomplete penetrance, possibly related to several gene...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Giordano, L, Deceglie, S, d'Adamo, P, Valentino, M L, La Morgia, C, Fracasso, F, Roberti, M, Cappellari, M, Petrosillo, G, Ciaravolo, S, Parente, D, Giordano, C, Maresca, A, Iommarini, L, Del Dotto, V, Ghelli, A M, Salomao, S R, Berezovsky, A, Belfort, R, Sadun, A A, Carelli, V, Loguercio Polosa, P, Cantatore, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720897/
https://ncbi.nlm.nih.gov/pubmed/26673666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.364
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