Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells

Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In the present stu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Lu, Q, Yan, S, Sun, H, Wang, W, Li, Y, Yang, X, Jiang, X, Che, Y, Xi, Z
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720880/
https://ncbi.nlm.nih.gov/pubmed/26633711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.344
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