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The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

Accumulation of the microtubule associated protein tau occurs in several neurodegenerative diseases including Alzheimer's disease (AD). The tau protein is intrinsically disordered, giving it unique structural properties that can be dynamically altered by post-translational modifications such as...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Sabbagh, Jonathan J., Dickey, Chad A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720746/
https://ncbi.nlm.nih.gov/pubmed/26834532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00003
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