Human autoreactive T cells recognize CD1b and phospholipids

In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have been difficult to isolate in humans. Here we report the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in iden...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Van Rhijn, Ildiko, van Berlo, Twan, Hilmenyuk, Tamara, Cheng, Tan-Yun, Wolf, Benjamin J., Tatituri, Raju V. V., Uldrich, Adam P., Napolitani, Giorgio, Cerundolo, Vincenzo, Altman, John D., Willemsen, Peter, Huang, Shouxiong, Rossjohn, Jamie, Besra, Gurdyal S., Brenner, Michael B., Godfrey, Dale I., Moody, D. Branch
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720340/
https://ncbi.nlm.nih.gov/pubmed/26621732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520947112
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