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Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau
Protein aggregation plays a critical role in the pathogenesis of neurodegenerative diseases, and the mechanism of its progression is poorly understood. Here, we examine the structural and dynamic characteristics of transiently evolving protein aggregates under ambient conditions by directly probing...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4720316/ https://ncbi.nlm.nih.gov/pubmed/26712030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504415113 |
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