Genome-wide DNA methylation analysis in melanoma reveals the importance of CpG methylation in MITF regulation

The microphthalmia-associated transcription factor (MITF) is a key regulator of melanocyte development and a lineage-specific oncogene in melanoma; a highly lethal cancer known for its unpredictable clinical course. MITF is regulated by multiple intracellular signaling pathways although the exact me...

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Pubblicato in:J Invest Dermatol
Autori principali: Lauss, Martin, Haq, Rizwan, Cirenajwis, Helena, Phung, Bengt, Harbst, Katja, Staaf, Johan, Rosengren, Frida, Holm, Karolina, Aine, Mattias, Jirström, Karin, Borg, Åke, Busch, Christian, Geisler, Jürgen, Lønning, Per Eystein, Ringnér, Markus, Howlin, Jillian, Fisher, David, Jönsson, Göran
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720161/
https://ncbi.nlm.nih.gov/pubmed/25705847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2015.61
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