p16 Hypermethylation and KRAS Mutation Are Independent Predictors of Cetuximab Plus FOLFIRI Chemotherapy in Patients with Metastatic Colorectal Cancer

PURPOSE: Hypermethylation of the CpG island of p16(INK4a) occurs in a significant proportion of colorectal cancer (CRC). We aimed to investigate its predictive role in CRC patients treated with 5-fluorouracil, leucovorin, irinotecan (FOLFIRI), and cetuximab. MATERIALS AND METHODS: Pyrosequencing was...

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Pubblicato in:Cancer Res Treat
Autori principali: Kim, Se Hyun, Park, Kyu Hyun, Shin, Sang Joon, Lee, Kang Young, Kim, Tae Il, Kim, Nam Kyu, Rha, Sun Young, Roh, Jae Kyung, Ahn, Joong Bae
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Cancer Association 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720076/
https://ncbi.nlm.nih.gov/pubmed/25943321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2014.314
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