Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells

CD4(+) follicular T helper (Tfh) cells play a prominent role in humoral immune responses, but the mechanisms of their accumulation and infection in AIDS remain unclear. Here we found that germinal center (GC) Tfh cells, defined here as CXCR5(+) PD-1(HIGH) CD4(+) T cells, do not express the HIV corec...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Xu, Huanbin, Wang, Xiaolei, Malam, Naomi, Aye, Pyone P., Alvarez, Xavier, Lackner, Andrew A., Veazey, Ronald S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719631/
https://ncbi.nlm.nih.gov/pubmed/26608323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02471-15
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