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A Single Amino Acid Change in the Marburg Virus Matrix Protein VP40 Provides a Replicative Advantage in a Species-Specific Manner

Marburg virus (MARV) induces severe hemorrhagic fever in humans and nonhuman primates but only transient nonlethal disease in rodents. However, sequential passages of MARV in rodents boosts infection leading to lethal disease. Guinea pig-adapted MARV contains one mutation in the viral matrix protein...

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Сохранить в:
Библиографические подробности
Опубликовано в: :J Virol
Главные авторы: Koehler, Alexander, Kolesnikova, Larissa, Welzel, Ulla, Schudt, Gordian, Herwig, Astrid, Becker, Stephan
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719610/
https://ncbi.nlm.nih.gov/pubmed/26581998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02670-15
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