Synonymous Deoptimization of Foot-and-Mouth Disease Virus Causes Attenuation In Vivo while Inducing a Strong Neutralizing Antibody Response

Codon bias deoptimization has been previously used to successfully attenuate human pathogens, including poliovirus, respiratory syncytial virus, and influenza virus. We have applied a similar technology to deoptimize the capsid-coding region (P1) of foot-and-mouth disease virus (FMDV). Despite the i...

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Vydáno v:J Virol
Hlavní autoři: Diaz-San Segundo, Fayna, Medina, Gisselle N., Ramirez-Medina, Elizabeth, Velazquez-Salinas, Lauro, Koster, Marla, Grubman, Marvin J., de los Santos, Teresa
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719607/
https://ncbi.nlm.nih.gov/pubmed/26581977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02167-15
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