Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice

The elderly are known to have enhanced susceptibility to infections and an impaired capacity to respond to vaccination. West Nile virus (WNV), a mosquito-borne flavivirus, has induced severe neurological symptoms, mostly in the elderly population. No vaccines are available for human use. Recent work...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Xie, Guorui, Luo, Huanle, Pang, Lan, Peng, Bi-hung, Winkelmann, Evandro, McGruder, Brenna, Hesse, Joseph, Whiteman, Melissa, Campbell, Gerald, Milligan, Gregg N., Cong, Yingzi, Barrett, Alan D., Wang, Tian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719598/
https://ncbi.nlm.nih.gov/pubmed/26581984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02488-15
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