Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses

Macrophages encounter flaviviruses early after injection by arthropod vectors. Using in vivo imaging of mice inoculated with firefly luciferase-expressing single-cycle flavivirus particles (FLUC-SCFV), we examined the initial dissemination of virus particles in the presence or absence of lymph node...

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Main Authors: Winkelmann, Evandro R., Widman, Douglas G., Xia, Jingya, Johnson, Alison J., van Rooijen, Nico, Mason, Peter W., Bourne, Nigel, Milligan, Gregg N.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939857/
https://ncbi.nlm.nih.gov/pubmed/24503091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.12.021
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