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A systematic analysis of acceptor specificity and reaction kinetics of five human α(2,3)sialyltransferases: Product inhibition studies illustrates reaction mechanism for ST3Gal-I

Sialyltransferases (STs) catalyze the addition of sialic acids to the non-reducing ends of glycoproteins and glycolipids. In this work, we examined the acceptor specificity of five human α(2,3)sialyltransferases, namely ST3Gal-I, -II, -III, -IV and -VI. K(M) values for each of these enzymes is prese...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Gupta, Rohitesh, Matta, Khushi L., Neelamegham, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719580/
https://ncbi.nlm.nih.gov/pubmed/26692484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.11.130
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