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Systematic humanization of yeast genes reveals conserved functions and genetic modularity
To determine whether genes retain ancestral functions over a billion years of evolution and to identify principles of deep evolutionary divergence, we replaced 414 essential yeast genes with their human orthologs, assaying for complementation of lethal growth defects upon loss of the yeast genes. Ne...
Sparad:
| I publikationen: | Science |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718922/ https://ncbi.nlm.nih.gov/pubmed/25999509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa0769 |
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