Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion

BACKGROUND: The impact of local anesthetics on regulation of glucose homeostasis by protein kinase B (Akt) and 5’-Adenosine monophosphate activated protein kinase (AMPK) is unclear but important because of the implications for both local anesthetic toxicity and its reversal by intravenous lipid emul...

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Опубликовано в: :Anesthesiology
Главные авторы: Fettiplace, Michael R., Kowal, Katarzyna, Ripper, Richard, Young, Alexandria, Lis, Kinga, Rubinstein, Israel, Bonini, Marcelo, Minshall, Richard, Weinberg, Guy
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718826/
https://ncbi.nlm.nih.gov/pubmed/26646023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000974
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