Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity

Hedgehog (Hh) pathway activation in R26-SmoM2;CAGGS-CreER mice, which carry a tamoxifen-inducible activated Smoothened allele (SmoM2), results in numerous microscopic tumor foci in mouse skeletal muscle. These tumors exhibit a highly differentiated myogenic phenotype and resemble human fetal rhabdom...

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Bibliographic Details
Published in:Exp Cell Res
Main Authors: Hettmer, Simone, Lin, Michael M., Tchessalova, Daria, Tortorici, Sara J., Castiglioni, Alessandra, Desai, Tushar, Mao, Junhao, McMahon, Andrew P., Wagers, Amy J.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718790/
https://ncbi.nlm.nih.gov/pubmed/26460176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2015.10.008
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