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Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity
Hedgehog (Hh) pathway activation in R26-SmoM2;CAGGS-CreER mice, which carry a tamoxifen-inducible activated Smoothened allele (SmoM2), results in numerous microscopic tumor foci in mouse skeletal muscle. These tumors exhibit a highly differentiated myogenic phenotype and resemble human fetal rhabdom...
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| Publicado no: | Exp Cell Res |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718790/ https://ncbi.nlm.nih.gov/pubmed/26460176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2015.10.008 |
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