Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics

Antibodies are currently the fastest-growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half-life. They have been conjugated to toxic payloads, PEGs, or radio-isotop...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Rashidian, Mohammad, Wang, Lu, Edens, Jerre G., Jacobsen, Johanne T., Hossain, Intekhab, Wang, Qifan, Victora, Gabriel D., Vasdev, Neil, Ploegh, Hidde, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718774/
https://ncbi.nlm.nih.gov/pubmed/26630549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507596
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